منابع مشابه
SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies.
Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. The catalytic activity of sulfatases resides in a unique formylglycine residue in their active site generated by the post-translational modification of a highly conserved cysteine...
متن کاملDevelopment of steroid sulfatase inhibitors.
Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone-dependent cancers such as those of the breast. Considerable progress has been made in the past two decades with regard to the discovery, design and development of STS inhibitors. We outline historical aspects of their deve...
متن کاملMultiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs.
Multiple sulfatase deficiency (MSD) is an inherited lysosomal storage disease characterized by the deficiency of at least seven sulfatases. The basic defect in MSD is thought to be in a post-translational modification common to all sulfatases. In accordance with this concept, RNAs of normal size and amount were detected in MSD fibroblasts for three sulfatases tested. cDNAs encoding arylsulfatas...
متن کاملSulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2.
Following a note from the authors to EMBO Reports and subsequent investigation by the Journal, the following errors are reported: We have come to realize that bands in Supplementary Fig 4A and B were derived from different gels and pasted on white background. Furthermore, several bands in Supplementary Fig 4A and B appear to be possible duplications (in particular, the bands in lanes 2, 6, 7 to...
متن کاملArylsulfatase K, a novel lysosomal sulfatase.
The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation. The loss of sulfatase activity has been linked to severe pathophysiological conditions such as lysosoma...
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ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1942
ISSN: 0369-4208,2185-0909
DOI: 10.1246/nikkashi1921.63.763